Research group head
Marko tries to bring the money in and keep the group on the straight and narrow. Ventures to lab on occasions, only to be scowled at by those who actually know that they are doing. He is still allowed to repair Emulsiflex as and when needed (=too often). |
Postdoctoral research associates
Paul Brear Paul is always busy curing cancer by inhibiting CK2α, Btk and other new targets with small molecules and peptides. In between research he runs the Crystallographic core facility and coordinates our Diamond Light Source beamtime. |
Caio Vinicius dos Reis Caio works with Alborada Drug Discovery Institute (ADDI) bringing FBDD component to their efforts to find treatments for neurogenerative diseases. |
Agnieszka Bogucka Agnieszka is part of a WT-funder project with Grøtli and Boren groups from University of Göteborg targeting liver pyruvate kinase for the treatment and prevention of non-alcoholic fatty liver disease (NAFLD). |
Shiv Kumar Sah Teli Shiv works on various extracellular targets with Bicycle Therapeutics to help with their inhibitor development processes. |
Lena Quambusch Lena uses chemical biology approaches to interrogate with TGF-ß family members mediated signaling. One part is validating Activin A as a druggable target in a proof-of-concept study utilizing Fragment-based Drug Discovery (FBDD) to evolve small molecule inhibitors to impair signaling. Lena is further applying chemical genetics to covalently link the Activin A dimer and assess the dependences of the inter-protomer angle towards signalling capacity. |
Research Assistant
Nicola Coker Gordon Nicola keeps the lab running and provides support to various research projects. |
Postgraduate students
Emma Belcher Emma is dealing with some pesky transmembrane receptors, taming them for structural and biophysical analyses to understand signalling mechanism better. |
Gwen Pyeatt Gwen is exploring the wonderful world of protein binding molecules to validate prevention of pro-form dissociation as a mechanism of activin A inhibition. Classes of molecules being investigated include designed ankyrin repeat proteins (DARPins), nanobodies, and de novo proteins. These binders could be put to use in the future as therapeutics for muscle atrophy disorders and fibrodysplasia ossificans progressiva and/or molecular tools to study activin A signalling. |
Alumni
Past Research staff, PhD students, Visitors…
Miha Renko | Postdoctoral Research Associate, 2021-2022 | Last observed: Department of Pharmacology |
Aleksandra Kruglikov | MPhil student 2021-2022 | Last observed: CRUK Cambridge Research Institute |
Aleksei Lulla | Postdoctoral Research Associate 2017-2022 | Last observed: Luisi Group, Department of Biochemistry |
Teodors Pantelejevs | PhD student 2017-2022 | Last observed: Latvian Institute of Organic Synthesis, Riga |
Matthew Ratcliff | PhD student 2017-2022 | Last observed: AstraZeneca, Cambridge |
Tonia Aristotelous | Postdoctoral Research Associate (with Univ of Herts) 2018-2020 | Last observed: Harvard University |
Beata Blaszczyk | Research Assistant 2015-2020 | Last observed: At Abzena, Cambridge |
Richard Zhou | MPhil 2019-2020 | Last observed: Department of Biochemistry, University of Oxford |
Katy Davis | PhD student (rotation) | Last observed: Dupree group, Cambridge |
Monique Liddar | Research Assistant | Last observed: St George’s, University of London |
Joseph McLoughlin | PhD Student, 2016-2019 | Last observed: Chesterton Community College, Cambridge |
Francesca Negrini | Visiting PhD student | Last observed: University of Bologna |
Lidia Vassilieva | PhD student from University of Helsinki | Last observed: University of Oxford |
Xuelu Wang | PhD student and postdoc (2012-2019) | Last observed: AstraZeneca, Cambridge |
Tom Cotton | PhD Student, 2013-2018 | Last observed: At Walter and Eliza Hall Institute, Melbourne, Australia |
Luana Ferrara | Protein Scientist, 2018-2019 | Last observed: Qkine, Cambridge |
Andrew Oliveira | Visiting PhD student, 2018 | Last observed: LNBio, Campinas, São Paulo, Brazil |
Gerhard Fischer | Postdoctoral Research Associate, 2012-2017 | Last observed, Bohringer Ingelheim, Wien, Austria |
Margherita Guaita | MPhil Student, 2016-2017 | Last observed: University of Manchester |
Marcelo Barreto Oliveira | Visiting PhD Student, 2016-2017 | Last observed: University of São Paulo, Brazil |
Clare Henry | PhD student, 2013-2017 | Last observed: Cultivated Biosciences, Switzerland |
Tommaso Moschetti | Postdoctoral research associate, 2011-2016 | Last observed: Illumina, Cambridge |
Maxim Rossmann | Postdoctoral research associate, 2011-2016 | Last observed: CIMR, Cambridge |
Jane “Cat” Donaldson | PhD student, 2010-2015 | Last observed: LaunchLabs, Alexandria Center for Life Sciences, New York, USA |
Piotr Gierszewski | Research assistant, 2015 | |
Migle Kisonaite | MPhil Student, 2014-2015 | Last observed in: NIDDK, NIH, Bethesda, USA |
Mathieu Rocaboy | Postdoctoral research associate, 2014-2015 | Last observed: Xpress Biologics, Belgium |
Marie Schloesser | Research Assistant, 2015 | Last observed: University of Liege, Belgium |
Mariana Rangel Pereira | Visiting PhD stdent, University of Sao Paulo, Brazil, 2013-2014 | Last observed: Hollfelder group, Cambridge |
Agata Sienkiewicz | Research Assistant, 2012-2014 | Last observed: CIMR, Cambridge |
Ruoqi “Emma” Xu | PhD student, 2010-2014 | Last observed:McCann Health Medical Communications |
Emily Blythe | MPhil student, 2012-2013 | Last observed: UCSF, San Francisco, USA |
Sandra Greive | Postdoctoral research associate, 2010-2012 | Last observed: DreamPore, Paris, France |
May Marsh | Postdoctoral research associate, 2008-2012 | Last observed: Paul Scherrer Institute, Switzerland |
Katharina Ravn | Research Assistant, 2009-2021 | Last observed: Copenhagen, Denmark |
Tim Sharpe | Postdoctoral research associate, 2010-2012 | Last observed: Biozentrum at University of Basel, Switzerland |
Ye “Leaf” Gu | PhD student, 2007-2011 | Last observed: American Express, London |
Eugene Valkov | Postdoctoral Research Associate, 2010-2011 | Last observed: National Cancer Institute, Frederick, USA |
Aman Sharma | Visiting MPhil student, 2009-2010 | Last observed: Oxford |
Lesley Dacks | Research Assistant, 2008 | Last observed: University of Alberta, Canada |
Sheena D’Arcy | “Fostered” PhD student, 2005-2008 & Postdoc, 2008 | Last observed: University of Texas at Dallas, Dallas, USA |
Adrian Harrington | PhD student, 2001-2005 | Last observed: Biogen |
David Story | Research Technician, 2002-2005 | Last observed: University of Edinburgh |
Axel Innis | PhD student, 1998-2002 | Last observed: University of Bordeaux, France |
Past undergraduate students
Sarah Bristow | Part II student 2023 |
Bocheng Xiao | Part II student 2023 |
Violette Chereau | Summer student 2022 |
Hannah Clarke | Part II student 2022 |
Jonty Corrin | Part II student 2022 |
Amir Rafati Fard | Part II student 2020-21 |
Tom Hammond | Part II student 2020 |
Alex Atkin | Part II student 2020 |
Cormac Creagh | Part II student 2019 |
Femke Ahlers | Part II student 2019 |
Oliwia Koczy | Summer student, 2018 |
Will Johnson | Part II student, 2018 |
Maria Chukanova | Part II student, 2018 |
Theresa Zeisner | Part II student, 2018 |
Vytaute Boreikaite | Part II student, 2017 |
Barbara Hogan | Part II student, 2017 |
Maddy Eno | Part II student, 2016 |
Michael Jenkyn Bedford | Part II student, 2016 |
Chris Wiles | Summer Student, 2015 |
James Wagstaff | Part II student, 2014 |
Cara Eldridge | Part II student, 2014 |
Matthew Morgan | Summer Student, 2013 |
Thomas Sanford | Part II student, 2013 |
Harshnira Patani | Part II student, 2013 |
Adam Tibbles | Summer student, 2012 |
Michael Dinan | Part II student, 2012 |
Jue Wang | Part II student, 2012 |
Hong Kin Ng | Part II student, 2011 |
Anne Streeter | Part II student, 2011 |
Siming Ma | Part II student, 2010 |
Sarah Gardner | Summer student, 2008 |
Bhamini Vaidialing | Part II student, 2008 |
Victoria Hendley | Part II student, 2007 |
Lara Osmotherly | Part II student, 2005 |
Lucy Williams | Part II student, 2004 |
James Robertson | Part II student, 2003 |
Kong Jie Kah | Part II student, 2002 |
Jose Pena | Summer student, 2000 |