Month: June 2017

Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2

Emma-Ruoqi Xu, Emily E. Blythe, Gerhard Fischer and  Marko Hyvönen

Journal of Biological Chemistry, 292:12516-12527, 2017
Pubmed ID: 28584056
PDB coordinates: 5NIR (3D view), 5NB8 (3D view)


Bone morphogenetic proteins (BMPs) are secreted growth factors that promote differentiation processes in embryogenesis and tissue development. Regulation of BMP signalling involves binding to a variety of extracellular proteins, among which are many von Willebrand factor C (vWC) domain-containing proteins. While the crystal structure of the complex of crossveinless-2 (CV-2) vWC1 and BMP-2 previously revealed one mode of the vWC:BMP binding mechanism, other vWC domains may bind to BMP differently.  Continue reading →

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