Month: January 2020

The thrombospondin module 1 domain of the matricellular protein CCN3 shows an atypical disulfide pattern and incomplete CWR layers

Emma-Ruoqi Xu, Aleix Lafita, Alex Bateman, Marko Hyvönen

Acta Crystallographica Section D Structural Biology D76:124-134 (2020)
DOI: 10.1107/S2059798319016747
Pubmed: 32038043

PDB coordinates:

6RK1 (3D view)


The members of the CCN (Cyr61/CTGF/Nov) family are a group of matricellular regulatory proteins that are essential to a wide range of functional pathways in cell signalling. Through interacting with extracellular matrix components and growth factors via one of their four domains, the CCN proteins are involved in critical biological processes such as angiogenesis, cell proliferation, bone development, fibrogenesis and tumorigenesis. Here, the crystal structure of the thrombospondin module 1 (TSP1) domain of CCN3 (previously known as Nov) is presented, which shares a similar three-stranded fold with the thrombo­spondin type 1 repeats of thrombospondin-1 and spondin-1, but with variations in the disulfide connectivity. Continue reading →

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