Emma-Ruoqi Xu, Aleix Lafita, Alex Bateman, Marko Hyvönen
Acta Crystallographica Section D Structural Biology D76:124-134 (2020)
DOI: 10.1107/S2059798319016747
Pubmed: 32038043
PDB coordinates:
Abstract
The members of the CCN (Cyr61/CTGF/Nov) family are a group of matricellular regulatory proteins that are essential to a wide range of functional pathways in cell signalling. Through interacting with extracellular matrix components and growth factors via one of their four domains, the CCN proteins are involved in critical biological processes such as angiogenesis, cell proliferation, bone development, fibrogenesis and tumorigenesis. Here, the of the thrombospondin module 1 (TSP1) domain of CCN3 (previously known as Nov) is presented, which shares a similar three-stranded fold with the thrombospondin type 1 repeats of thrombospondin-1 and spondin-1, but with variations in the disulfide connectivity. Continue reading →